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T cells are Important: SARS-CoV-2 Variants & Vaccine Immune Response
To understand immune evasion of emerging variants and vaccine responses, researchers need to go beyond the antibody response and study the T-cell immune response to SARS-CoV-2. T cells generate...
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Effects of COVID-19 across organs and systems in healthy and...
Understanding the whole-system effects of COVID-19 and the immune system’s response to the virus is vital in vaccine and therapy development. Research shows that both asymptomatic and symptomatic...
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Unraveling the mysteries of the adaptive immune system in autoimmune diseases
Under conditions of normal immune function, T cells defend the body against foreign antigens. However, aberrant responses to self- and non-self-antigens result in autoimmune disease, in which healthy...
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CMV infection and its impact on the adaptive immune system
Cytomegalovirus (CMV) is a globally widespread virus with a seroprevalence of 50–100%. (1–3) CMV can be transmitted from an infected person via body fluids (e.g. saliva, breast milk, blood, semen, and...
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How HLA influences the T-cell repertoire and disease
Classic major histocompatibility complex (MHC) proteins, also known as human leukocyte antigen (HLA) proteins in humans, play an essential role in immune function and regulation, including influencing...
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Gaining insights into T-cell therapies with immunosequencing
Immunotherapies have revolutionized the cancer therapy landscape (1,2) and hold potential in other areas, including autoimmune diseases, allergies, (3) and organ transplant. (1,4,5) There are several...
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Uncovering the role of γδ T cells in adaptive immunity
Previously, when we’ve talked about T cells, we’ve focused on the most abundant type of T cells, the ɑβ T cells. These include CD4+ and CD8+ T cells and represent up to 95% of the T cells in the body....
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The Omicron variant: T cells provide a reason to be optimistic about immunity...
It’s been three months since the first case of Omicron was identified in the US. Initial reports that Omicron is more contagious but causes less severe disease appear to be substantiated. Fortunately,...
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Recognizing the accomplishments of women in science: A conversation with Ana...
Ana M. Bolivar Adaptive Biotechnologies is committed to recognizing and promoting the work of women scientists across immune science because we understand that greater diversity leads to greater...
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Applications of immunosequencing in transplant research
Despite advances in transplant research, transplant recipients are still at risk of mortality and morbidity due to complications such as severe infection, graft-versus-host disease (GVHD), and graft...
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